their corresponding DGC conditioned media (CM). glioblastoma (GBM) over regular examples in multiple datasets. The desk displays the gene established enrichment analysisGene Established Enrichment Analysis (GSEA) result, ITI214 indicating significant positive enrichment of multiple TGF–related gene pieces in GBM over regular in multiple publicly obtainable datasets. Darker to lighter crimson indicates the best to minimum normalized enrichment rating (NES), as the image ‘%’ and green color suggest the significant gene pieces p-Value 0.05 is known as significant. NA, unavailable. elife-78972-fig1-data8.zip (13K) GUID:?21188DE4-D96B-49C1-8291-D7B407415C8B Amount 1source data 9: Supply data used to create Amount 1source data 8. elife-78972-fig1-data9.zip (16M) GUID:?5298D311-AB9F-4EFA-B94B-79BC04EBD3A2 Amount 1source data ITI214 10: Mesenchymal gene expression signature and TGF- signaling pathway Rabbit Polyclonal to IFI6 are enriched in differentiated glioma cells (DGCs). Gene Place Variance Evaluation (GSVA) output signifies the molecular subtypes from the glioma stem-like cells (GSCs) and DGCs of MGG4, MGG6, and MGG8 (each in triplicates). The darkest reddish indicates the highest GSVA value for any subtype indicating the highest enrichment in that particular sample, with ITI214 decreasing color intensity indicating a lower enrichment of the subtypes. The table also shows the GSVA score for the TGF- hallmark gene set from MSigDb across the multiple data units. The darkest reddish depicts the highest enrichment, and progressive lighter colors indicate gradually decreasing enrichment. elife-78972-fig1-data10.zip (33K) GUID:?224FED6D-91E2-458F-9FF6-51FACBE51828 Figure 1source data 11: Source data used to generate Figure 1source data 10. elife-78972-fig1-data11.zip (382K) GUID:?B6907593-1FBB-48C6-BEF6-D1676ED508AB Physique 1figure product 1source data 1: Source data used to generate Figure 1, Physique 1figure product 1A B. elife-78972-fig1-figsupp1-data1.zip (55K) GUID:?DD9773E5-FA3C-46AC-8E99-D665162E0E4A Physique 1figure supplement 2source data 1: Source data used to generate Physique 1figure supplement 2. elife-78972-fig1-figsupp2-data1.zip (1.3M) GUID:?A972C032-572A-40D5-B893-03D0B62F4C92 Physique 1figure product 3source data 1: Source data used to generate Figure 1figure product 3ACD. elife-78972-fig1-figsupp3-data1.zip (406K) GUID:?99482457-0711-4A1C-AF25-8D409D7741DF Physique 2source data ITI214 1: Source data used to generate Physique 2C. elife-78972-fig2-data1.zip (8.7M) GUID:?09DE5422-6089-4F2B-BD38-9505D59CE819 Figure 2source data 2: Source data used to generate Figure 2D. elife-78972-fig2-data2.zip (35K) GUID:?50BA9A84-D095-46E0-A8EE-7FD133528B4A Physique 2figure supplement 1source data 1: Source data used to generate Physique 2figure supplement 1ACE. elife-78972-fig2-figsupp1-data1.zip (1.1M) GUID:?966FBE72-DFFD-4A2E-9A22-D916DBD6D4DF Physique 2figure product 2source data 1: Source data used to generate Figure 2figure product 2ACE. elife-78972-fig2-figsupp2-data1.zip (384K) GUID:?E9AB0D1E-369D-4A48-8A15-FB4C268B0B66 Physique 2figure product 3source data 1: Source data used to generate Figure 2figure product 3ACD. elife-78972-fig2-figsupp3-data1.zip (2.3M) GUID:?790ECDA3-AAAF-4659-A28C-C3EA10DB1DC5 Figure 2figure supplement 4source data 1: Source data used to generate Figure 2figure supplement 4A B. elife-78972-fig2-figsupp4-data1.zip (1.1M) GUID:?7ECE8AA0-5755-4BAD-8981-20C0B75F387E Physique 2figure supplement 5source data 1: Source data used to generate Physique 2figure supplement 5ACG. elife-78972-fig2-figsupp5-data1.zip (1.8M) GUID:?9114608E-B977-4638-A058-36C958E3F952 Physique 2figure product 6source data 1: Source data used to generate Figure 2figure product 6ACD. elife-78972-fig2-figsupp6-data1.zip (372K) GUID:?666F853E-5DC1-4517-ABBD-D456CBDD7C95 Figure 2figure supplement 7source data 1: Source data used to generate Figure 2figure supplement 7. elife-78972-fig2-figsupp7-data1.zip (478K) GUID:?B7994114-C669-414C-B272-ACC13B4B04D8 Figure 3source data 1: Source data used to generate Figure 3A. elife-78972-fig3-data1.zip (1.3M) GUID:?88CA9810-17DD-44F4-B32D-2D8EB8FC353B Physique 3source data 2: Source data used to generate Physique 3B. elife-78972-fig3-data2.zip (6.9K) GUID:?CB97C9E8-FA1E-48B2-942F-8E34CB506D2D Physique 3source data 3: Source data used to generate Physique 3C. elife-78972-fig3-data3.zip (6.9K) GUID:?B18E4270-1183-454D-980F-7F9E846DEDB3 Figure 3source data 4: Source data used to generate Figure 3D. elife-78972-fig3-data4.zip (7.6K) GUID:?BD948017-07B1-49AA-89AD-21515ACDF1A2 Physique 3source data 5: Source data used to generate Physique 3E. elife-78972-fig3-data5.zip (1.1M) GUID:?67253C54-0542-430A-8783-ACE69FB1C3FA Physique 3source data 6: Source data used to generate Physique 3F. elife-78972-fig3-data6.zip (6.6K) GUID:?C949D7AB-AE36-474D-8C86-B2CCD627EC00 Figure 3source data 7: Source data used to generate Figure 3G. elife-78972-fig3-data7.zip (7.9K) GUID:?4FC932C9-AE1C-4BB6-81A3-EFBF0A3C18B2 Physique 3source data 8: Source data used to generate Physique 3H. elife-78972-fig3-data8.zip (127K) GUID:?8C330262-391E-47EE-8D48-C9BDBA3283EF Physique 3source data 9: Source data used to generate Physique 3. elife-78972-fig3-data9.zip (451K) GUID:?6AC3E7BE-42B4-4EEA-891D-CF36587C73EE Physique 3source data 10: Source data used to generate Physique 3J. elife-78972-fig3-data10.zip (6.7K) GUID:?F79925AE-D09C-4F0A-A7B7-C761A367B4EF Physique 3figure product 1source data 1: ITI214 Source data used to generate Physique 3figure product 1ACE . elife-78972-fig3-figsupp1-data1.zip (2.0M).